Pseudomonas aeruginosa

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Fundamental Research Grant Scheme (FRGS) 2017 - Pharmacological effects of a new compound phomopsidione on extensively drug resistant Pseudomonas aeruginosa.

 

ABSTRACT
Pseudomonas aeruginosa is an opportunistic Gram negative bacterium that causes nosocomial and ventilator associated pneumoniae. In Malaysia, antibiotic resistance in clinical isolates of P. aeruginosa has been reported. The term “extensively drug resistant (XDR)” is used to describe a bacterial strain that is resistant to at least 3 classes of antibiotics. XDR P. aeruginosa leads to a significant increase of morbidity and mortality in humans. Furthermore, the antibiotic therapies currently available are not effective against these bacterial strains. In previous study, we discovered a new compound, Phomopsidione (3-hydroxy-5-methoxyhex-5-ene-2,4-dione) that exhibited excellent bactericidal activity on XDR P. aeruginosa. However, the pharmacological effects and antibiotic mechanism of this compound remain unknown. Thus, this proposed project aims to determine
the pharmacological effects and the antibiotic mechanism of phomopsidione on XDR P. aeruginosa.
By the end of this project, a theory on pharmacological effects and antibiotic mechanism of phomopsidione will be available. This theory can be used in the design of clinical trials for this antibiotic to treat P. aeruginosa infections. This proposed study is important to provide an alternative
treatment to combat drug-resistant bacteria.


NOVELTY
By the end of this project, a theory on pharmacological effects and antibiotic mechanism of phomopsidione will be available. So far, we are the only group who working with this compound, and the literature available on this compound is extremely scarce. This study is crucial to generate new knoeledge on the new compound, phomopsidione. The theory obtained can be further applied to evaluate the medical significance and possible clinical placement of this compound.


USEFULNESS
The output of this proposed study is important to evaluate the medical significance and possible clinical placement of this compound. The understanding of the pharmacological effects and antibiotic mechanism are very important for clinical trial design, in order to develop a new drug application (NDA) to combat multidrug resistant Gram negative pathogens.
 

Contact

For further information please contact:
Dr Tong Woei Yenn
Section of Bioengineering
Malaysian Institute of Chemical and Bioengineering Technology
University of Kuala Lumpur
Vendor City, Taboh Naning, 78000 Alor Gajah, Melaka
Phone: +606 551 2000, Fax: +606 551 2001
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

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